I've always liked the following quote, even though I disagree with the certainty which Nietzsche (unsurprisingly) dooms the human race to a future in which humans are nothing.
I don't find it outside the realm of possibility that the human intellect will one day shape the universe to the will of its wielders.
Once upon a time, in some out of the way corner of that universe which is dispersed into numberless twinkling solar systems, there was a star upon which clever beasts invented knowing. That was the most arrogant and mendacious minute of "world history," but nevertheless, it was only a minute. After nature had drawn a few breaths, the star cooled and congealed, and the clever beasts had to die. One might invent such a fable, and yet he still would not have adequately illustrated how miserable, how shadowy and transient, how aimless and arbitrary the human intellect looks within nature. There were eternities during which it did not exist. And when it is all over with the human intellect, nothing will have happened.
Nietzsche, On Truth and Lies in a Nonmoral Sense
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We already do shape the universe, we are prisoners of our own reality. When we are gone that reality ceases to exist. It's kind of like the proverbial tree falling in the forest.